Research Assistant I
The Jackson lab is seeking a motivated and enthusiastic Research Assistant I to join our team to work on structures and functions of membrane trafficking protein complexes in cell biology and human disease. We employ a range of techniques in biochemistry, biophysics, structural biology, and cell biology to investigate cargo recognition, assembly, and regulation of coats. We aim to understand both the fundamental cell biology of how coats mediate trafficking pathways, as well as the molecular bases for neurological diseases associated with mutated coats.
This position will include the following responsibilities:
Previous research experience is strongly preferred. Experience with relevant techniques is advantageous but not required. Applicants must have a bachelor’s degree in the natural sciences.
Please send a CV or resume and cover letter (both required) and 1-2 letters of recommendation to Lauren Jackson (firstname.lastname@example.org). We will consider candidates until the position is filled; the tentative start date is September 1, 2018.
The Jackson lab is funded by NIH NIGMS and the Pew Charitable Trusts, and the lab is affiliated with the Vanderbilt Center for Structural Biology, Vanderbilt Brain Institute, and Epithelial Biology Center. We are located in Nashville, TN, a vibrant city with fantastic neighborhoods, restaurants, cafés, music, parks, and outdoor activities.
.The Jackson lab is actively recruiting graduate students and has multiple exciting projects available for 2018-19. We always pair students with experienced lab members to help and support your training. We feel it's important for students to have their own project but also to interact with other lab members to see the full breadth of what we do. Please email Lauren if you're interested!
Crystallization & crystallography
1. cell cycle protein domain
2. multiple trafficking protein domains
Electron microscopy of endosomal coat complexes
1. Single particle cryoEM data processing & model refinement
2. F20 data collection & processing to obtain class averages
3. Single particle data collection (Titan Krios comes online here late 2018)
1. Cargo assays to test structure-based assembly mechanisms
2. Imaging in mammalian cultured cell lines
1. Protein expression & purification projects a-plenty
2. Pulldown assays to test direct binding between coats & new protein partners
Meredith won the Graduate Student Research Excellence Award in Biological Sciences at our annual departmental retreat. We are so proud of her accomplishments over her Ph.D. and wish her the best as she begins her postdoc at UNC Chapel Hill!
We held our annual lab retreat at Pinewood Social in downtown Nashville. A few highlights before we were displaced by not one, but two, bachelorette parties... :/
Chris has been awarded a Vanderbilt Undergraduate Summer Research Program fellowship for summer 2018. This is a highly competitive program and rare for a rising junior to get a slot. Congratulations Chris!
Meredith Frazier successfully defended her thesis on March 12th, We're so proud of you! Party pictures to follow soon...
Emily Linton and Kaylee Johnson have joined the lab for IGP rotation 4. Delighted to have you ladies with us!
Alex Davies's beautiful work on the proteomics of AP4 coated vesicles is out on Bioarxiv today. We're delighted to continue our collaboration with Alex, Scottie, and Georg!
Check it out here