.The Jackson lab is actively recruiting graduate students and has multiple exciting projects available for 2018-19. We always pair students with experienced lab members to help and support your training. We feel it's important for students to have their own project but also to interact with other lab members to see the full breadth of what we do. Please email Lauren if you're interested!
Crystallization & crystallography
1. cell cycle protein domain
2. multiple trafficking protein domains
Electron microscopy of endosomal coat complexes
1. Single particle cryoEM data processing & model refinement
2. F20 data collection & processing to obtain class averages
3. Single particle data collection (Titan Krios comes online here late 2018)
1. Cargo assays to test structure-based assembly mechanisms
2. Imaging in mammalian cultured cell lines
1. Protein expression & purification projects a-plenty
2. Pulldown assays to test direct binding between coats & new protein partners
Meredith won the Graduate Student Research Excellence Award in Biological Sciences at our annual departmental retreat. We are so proud of her accomplishments over her Ph.D. and wish her the best as she begins her postdoc at UNC Chapel Hill!
We held our annual lab retreat at Pinewood Social in downtown Nashville. A few highlights before we were displaced by not one, but two, bachelorette parties... :/
Chris has been awarded a Vanderbilt Undergraduate Summer Research Program fellowship for summer 2018. This is a highly competitive program and rare for a rising junior to get a slot. Congratulations Chris!
Meredith Frazier successfully defended her thesis on March 12th, We're so proud of you! Party pictures to follow soon...
Emily Linton and Kaylee Johnson have joined the lab for IGP rotation 4. Delighted to have you ladies with us!
Alex Davies's beautiful work on the proteomics of AP4 coated vesicles is out on Bioarxiv today. We're delighted to continue our collaboration with Alex, Scottie, and Georg!
Check it out here
The Jackson Lab is actively recruiting excellent and motivated graduate students for high impact projects that span structural biology, cell biology, and biochemistry of membrane trafficking proteins. Send Lauren an email if you're interested in any of the following options for next year.
* CryoEM. We have a trafficking coat protein complex in ice, and we're already at 13A! Great opportunity to learn to prepare samples, collect and analyze data, and build models.
* Crystallization/crystallography projects. We have confirmed several new binding partners for our trafficking proteins, so we are ready to undertake crystal trials.
* Biophysics & biochemistry. Multiple opportunities to learn how to use calorimetry (ITC) to quantify binding affinities and structure-based mutagenesis to test binding interfaces.
* Microscopy projects in the Nikon Center. Great chance to work with graduate student to use our excellent imaging facilities.